Chronic and Neurotropic: A Paradigm-Challenging Case of Dengue Virus Encephalitis in a Patient With Advanced HIV Infection

A 32-year-old female with advanced human immunodeficiency virus infection presented to an Australian hospital with subacute, worsening symptoms of encephalitis. Metagenomic sequencing and Dengue NS3 antigen staining of brain tissue confirmed active dengue virus (DENV) encephalitis. The most recent p...

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Bibliographic Details
Published in:Clinical infectious diseases 2024-08, Vol.79 (2), p.498-501
Main Authors: Marinelli, Tina, Masters, Jeffrey, Buckland, Michael E, Lee, Maggie, Rawlinson, William, Kim, Ki Wook, Urriola, Nicolas, van Hal, Sebastiaan
Format: Article
Language:English
Subjects:
Adult
Australia
Brain - diagnostic imaging
Brain - pathology
Brain - virology
Chronic Disease
Dengue - complications
Dengue - diagnosis
Dengue Virus - genetics
Encephalitis, Viral - diagnosis
Encephalitis, Viral - virology
Female
HIV Infections - complications
Humans
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Description
Summary:A 32-year-old female with advanced human immunodeficiency virus infection presented to an Australian hospital with subacute, worsening symptoms of encephalitis. Metagenomic sequencing and Dengue NS3 antigen staining of brain tissue confirmed active dengue virus (DENV) encephalitis. The most recent possible DENV exposure was months prior in West Africa, indicating chronicity.
ISSN:1058-4838
1537-6591
1537-6591
DOI:10.1093/cid/ciae061