Green synthesis of MnO 2 NPs using Arabic gum: assessing its potential antiviral activity against influenza A/H1N1

The antiviral properties of metal nanoparticles against various viruses, including those resistant to drugs, are currently a subject of intensive research. Recently, the green synthesis of nanoparticles and their anti-viral function have attracted a lot of attention. Previous studies have shown prom...

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Bibliographic Details
Published in:Virology journal 2024-02, Vol.21 (1), p.48
Main Authors: Baghban, Neda, Momeni, Safieh, Behboudi, Emad, Dianat-Moghadam, Hassan, Darabi, Amirhossein, Targhi, Hadiseh Shokouhi, Keshavarz, Mohsen
Format: Article
Language:English
Subjects:
Antiviral Agents - pharmacology
Humans
Influenza A Virus, H1N1 Subtype
Influenza, Human - drug therapy
Manganese Compounds - pharmacology
Metal Nanoparticles - chemistry
Molecular Docking Simulation
Oxides - pharmacology
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Summary:The antiviral properties of metal nanoparticles against various viruses, including those resistant to drugs, are currently a subject of intensive research. Recently, the green synthesis of nanoparticles and their anti-viral function have attracted a lot of attention. Previous studies have shown promising results in the use of Arabic gum for the green synthesis of nanoparticles with strong antiviral properties. In this study we aimed to investigate the antiviral effects of MnO nanoparticles (MnO -NPs) synthesized using Arabic gum, particularly against the influenza virus. Arabic gum was used as a natural polymer to extract and synthesize MnO -NPs using a green chemistry approach. The synthesized MnO -NPs were characterized using SEM and TEM. To evaluate virus titration, cytotoxicity, and antiviral activity, TCID50, MTT, and Hemagglutination assay (HA) were performed, respectively. Molecular docking studies were also performed to investigate the potential antiviral activity of the synthesized MnO -NPs against the influenza virus. The molecular docking was carried out using AutoDock Vina software followed by an analysis with VMD software to investigate the interaction between Arabic gum and the hemagglutinin protein. Simultaneous combination treatment with the green-synthesized MnO -NPs resulted in a 3.5 log HA decrement and 69.7% cellular protection, which demonstrated the most significant difference in cellular protection compared to the virus control group (p-value 
ISSN:1743-422X