Diagnostic value of 18 F - PSMA - 1007 PET/CT combined with prostate specific antigen derived indicators in gray area prostate cancer

The incidence of prostate cancer is increasing every year, and precision diagnosis and treatment can help reduce unnecessary prostate punctures for prostate cancer patients in the gray area. This study aims to investigate the diagnostic value of F-prostate specific membrane antigen (PSMA) imaging co...

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Published in:Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban 2023-12, Vol.48 (12), p.1812
Main Authors: Guo, Sheng, Zhou, Chuan, Zhang, Yunfeng, Wang, Dong, Niu, Tao, Zhou, Fenghai
Format: Article
Language:English
Subjects:
Humans
Male
Niacinamide - analogs & derivatives
Oligopeptides
Positron Emission Tomography Computed Tomography
Prostate-Specific Antigen
Prostatic Neoplasms - diagnostic imaging
Retrospective Studies
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Summary:The incidence of prostate cancer is increasing every year, and precision diagnosis and treatment can help reduce unnecessary prostate punctures for prostate cancer patients in the gray area. This study aims to investigate the diagnostic value of F-prostate specific membrane antigen (PSMA) imaging combined with prostate specific antigen (PSA)-derived indicators for gray zone prostate cancer. A total of 107 patients who underwent F-PSMA PET/CT imaging for suspicious prostate cancer with tPSA of 4 to 10 μg/L (PSA gray zone) in a hospital were retrospectively included, and were divided into a prostate cancer group and a non-prostate cancer group based on pathological findings. Patients underwent PSA testing, F-PSMA, and abdominal ultrasound, and age, tPSA, fPSA, f/tPSA, prostate volume, PSA density (PSAD), maximum standardized uptake value (SUVmax), and molecular imaging prostate specific membrane antigen (miPSMA) score were compared between the 2 groups. Multivariate logistic regression was used to analyze the influencing factors the diagnosis of gray zone prostate cancer. Receiver operating characteristic (ROC) curves were constructed to evaluate the efficacy of PSAD and SUVmax alone and in combination in diagnosing gray zone prostate cancer. The volume of the prostate cancer group [42.00(34.00, 58.00) cm vs 49.00(41.27, 60.41) cm ] was smaller than that of the non-prostate cancer group ( =-2.376, =0.017), and the PSAD [(0.18±0.06) μg/(L·cm ) vs 0.15±0.05 μg/(L·cm )] and SUVmax [18.63(8.03, 28.57) vs 9.33(5.90, 13.52)] were higher than those in the non-prostate cancer group (both
ISSN:1672-7347