Nomogram for predicting the risk of nonalcoholic fatty liver disease in older adults in Qingdao, China: A cross-sectional study

• Published in: Asia Pacific Journal of Clinical Nutrition 2024-03, Vol.33 (1), p.83-93
• Main Authors: Wang, Zhi, Cui, Jing, Li, Xiaojing, Gao, Ruili, Feng, Enqiang, Luo, Guoqiang, Guo, Baozhu, Wu, Haojia, Sun, Yongye, Sun, Jianping
• Format: Article
• Language: English
• Subjects: Aged; China - epidemiology; Cross-Sectional Studies; Diseases; Evaluation; Humans; Liver; Methodology; Nomograms; Non-alcoholic Fatty Liver Disease - diagnosis; Non-alcoholic Fatty Liver Disease - epidemiology; Original; Population; Reproducibility of Results; Risk Factors; Ultrasonic imaging
• ISSN: 0964-7058; 1440-6047; 1440-6047
• DOI: 10.6133/apjcn.202403_33(1).0009

Background and Objectives: To explore the risk factors for non-alcoholic fatty liver disease (NAFLD) and to establish a non-invasive tool for the screening of NAFLD in an older adult population. Methods and Study Design: A total of 131,161 participants were included in this cross-sectional study. Participants were randomly divided into training and validation sets (7:3). The least absolute shrinkage and selection operator method was used to screen risk factors. Multivariate logistic regression was employed to develop a nomogram, which was made available online. Receiver operating characteristic curve analysis, calibration plots, and decision curve analysis were used to validate the discrimination, calibration, and clinical practicability of the nomogram. Sex and age subgroup analyses were conducted to further validate the reliability of the model. Results: Nine variables were identified for inclusion in the nomogram (age, sex, waist circumference, body mass index, exercise frequency, systolic blood pressure, fasting plasma glucose, alanine aminotransferase, and low-density lipoprotein cholesterol). The area under the receiver operating characteristic curve values were 0.793 and 0.790 for the training set and the validation set, respectively. The calibration plots and decision curve analyses showed good calibration and clinical utility. Subgroup analyses demonstrated consistent discriminatory ability in different sex and age sub-groups. Conclusions: This study established and validated a new nomogram model for evaluating the risk of NAFLD among older adults. The nomogram had good discriminatory performance and is a non-invasive and convenient tool for the screening of NAFLD in older adults.