Evaluation of the clinical usefulness of pancreatic alpha amylase as a novel biomarker in dogs with acute pancreatitis: a pilot study

Pancreatic alpha amylase (P-AMY) is used as a biomarker of acute pancreatitis (AP) in human medicine. To our knowledge, there are no studies evaluating the usefulness of P-AMY in dogs with AP. In this study, we evaluated the diagnostic value of P-AMY, currently not verified in veterinary medicine. T...

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Bibliographic Details
Published in:The Veterinary quarterly 2024-12, Vol.44 (1), p.1-7
Main Authors: Kim, Keon, Kim, Hee-hong, Joo, Jae-Beom, Kim, Ock-Kyu, Park, Sin-Wook, Suh, Guk-Hyun, Ro, Woong-Bin, Lee, Chang-Min
Format: Article
Language:English
Subjects:
Abnormalities
Acute pancreatitis
Amylases
Biomarkers
Correlation analysis
Diagnostic systems
Dogs
Inflammation
Inflammatory response
Lipase
Pancreas
pancreatic-alpha amylase
Pancreatitis
Sensitivity analysis
Systemic inflammatory response syndrome
Veterinary medicine
α-Amylase
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Summary:Pancreatic alpha amylase (P-AMY) is used as a biomarker of acute pancreatitis (AP) in human medicine. To our knowledge, there are no studies evaluating the usefulness of P-AMY in dogs with AP. In this study, we evaluated the diagnostic value of P-AMY, currently not verified in veterinary medicine. The AP group (n = 40) consisted of dogs with AP diagnosed using clinical signs and laboratory examinations, including abnormal canine pancreatic lipase (cPL) concentration, and compatible abdominal ultrasound examination at first presentation. Evaluation of the canine AP severity (CAPS) score was performed. The control group (n = 38) was composed of normal dogs without any abnormalities in clinical findings, blood exams or diagnostic imaging. The correlation of P-AMY with cPL was confirmed by Pearson's correlation analysis (r = 0.564, p 
ISSN:0165-2176
1875-5941
DOI:10.1080/01652176.2024.2326007