Evaluation of the clinical usefulness of pancreatic alpha amylase as a novel biomarker in dogs with acute pancreatitis: a pilot study

Pancreatic alpha amylase (P-AMY) is used as a biomarker of acute pancreatitis (AP) in human medicine. To our knowledge, there are no studies evaluating the usefulness of P-AMY in dogs with AP. In this study, we evaluated the diagnostic value of P-AMY, currently not verified in veterinary medicine. T...

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Published in:The Veterinary quarterly 2024-12, Vol.44 (1), p.1-7
Main Authors: Kim, Keon, Kim, Hee-hong, Joo, Jae-Beom, Kim, Ock-Kyu, Park, Sin-Wook, Suh, Guk-Hyun, Ro, Woong-Bin, Lee, Chang-Min
Format: Article
Language:English
Subjects:
Abnormalities
Acute pancreatitis
Amylases
Biomarkers
Correlation analysis
Diagnostic systems
Dogs
Inflammation
Inflammatory response
Lipase
Pancreas
pancreatic-alpha amylase
Pancreatitis
Sensitivity analysis
Systemic inflammatory response syndrome
Veterinary medicine
α-Amylase
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container_start_page 1
container_title The Veterinary quarterly
container_volume 44
creator Kim, Keon
Kim, Hee-hong
Joo, Jae-Beom
Kim, Ock-Kyu
Park, Sin-Wook
Suh, Guk-Hyun
Ro, Woong-Bin
Lee, Chang-Min
description Pancreatic alpha amylase (P-AMY) is used as a biomarker of acute pancreatitis (AP) in human medicine. To our knowledge, there are no studies evaluating the usefulness of P-AMY in dogs with AP. In this study, we evaluated the diagnostic value of P-AMY, currently not verified in veterinary medicine. The AP group (n = 40) consisted of dogs with AP diagnosed using clinical signs and laboratory examinations, including abnormal canine pancreatic lipase (cPL) concentration, and compatible abdominal ultrasound examination at first presentation. Evaluation of the canine AP severity (CAPS) score was performed. The control group (n = 38) was composed of normal dogs without any abnormalities in clinical findings, blood exams or diagnostic imaging. The correlation of P-AMY with cPL was confirmed by Pearson's correlation analysis (r = 0.564, p 
doi_str_mv 10.1080/01652176.2024.2326007
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To our knowledge, there are no studies evaluating the usefulness of P-AMY in dogs with AP. In this study, we evaluated the diagnostic value of P-AMY, currently not verified in veterinary medicine. The AP group (n = 40) consisted of dogs with AP diagnosed using clinical signs and laboratory examinations, including abnormal canine pancreatic lipase (cPL) concentration, and compatible abdominal ultrasound examination at first presentation. Evaluation of the canine AP severity (CAPS) score was performed. The control group (n = 38) was composed of normal dogs without any abnormalities in clinical findings, blood exams or diagnostic imaging. The correlation of P-AMY with cPL was confirmed by Pearson's correlation analysis (r = 0.564, p &lt; .001). The sensitivity and specificity for the most appropriate cut-off values of P-AMY were recorded similar to the values of DGGR. The dogs with AP and CAPS ≥11 had significantly higher serum P-AMY (p = .016) contrary to DGGR lipase and cPL. Furthermore, there was a significant difference in the median P-AMY dependent on the presence of systemic inflammatory response syndrome (p = .001). P-AMY showed similar level of diagnostic accuracy along with sensitivity and specificity compared to DGGR lipase. In addition, P-AMY showed a significant association with CAPS score, contrary to cPL and DGGR lipase. Along with other biomarkers associated with AP, P-AMY has the potential of usefulness as a supportive diagnostic and prognostic biomarker of AP in dogs.</description><identifier>ISSN: 0165-2176</identifier><identifier>EISSN: 1875-5941</identifier><identifier>DOI: 10.1080/01652176.2024.2326007</identifier><identifier>PMID: 38497337</identifier><language>eng</language><publisher>England: Taylor &amp; Francis</publisher><subject>Abnormalities ; Acute pancreatitis ; Amylases ; Biomarkers ; Correlation analysis ; Diagnostic systems ; Dogs ; Inflammation ; Inflammatory response ; Lipase ; Pancreas ; pancreatic-alpha amylase ; Pancreatitis ; Sensitivity analysis ; Systemic inflammatory response syndrome ; Veterinary medicine ; α-Amylase</subject><ispartof>The Veterinary quarterly, 2024-12, Vol.44 (1), p.1-7</ispartof><rights>2024 The Author(s). Published by Informa UK Limited, trading as Taylor &amp; Francis Group. 2024</rights><rights>2024 The Author(s). 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To our knowledge, there are no studies evaluating the usefulness of P-AMY in dogs with AP. In this study, we evaluated the diagnostic value of P-AMY, currently not verified in veterinary medicine. The AP group (n = 40) consisted of dogs with AP diagnosed using clinical signs and laboratory examinations, including abnormal canine pancreatic lipase (cPL) concentration, and compatible abdominal ultrasound examination at first presentation. Evaluation of the canine AP severity (CAPS) score was performed. The control group (n = 38) was composed of normal dogs without any abnormalities in clinical findings, blood exams or diagnostic imaging. The correlation of P-AMY with cPL was confirmed by Pearson's correlation analysis (r = 0.564, p &lt; .001). The sensitivity and specificity for the most appropriate cut-off values of P-AMY were recorded similar to the values of DGGR. The dogs with AP and CAPS ≥11 had significantly higher serum P-AMY (p = .016) contrary to DGGR lipase and cPL. 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To our knowledge, there are no studies evaluating the usefulness of P-AMY in dogs with AP. In this study, we evaluated the diagnostic value of P-AMY, currently not verified in veterinary medicine. The AP group (n = 40) consisted of dogs with AP diagnosed using clinical signs and laboratory examinations, including abnormal canine pancreatic lipase (cPL) concentration, and compatible abdominal ultrasound examination at first presentation. Evaluation of the canine AP severity (CAPS) score was performed. The control group (n = 38) was composed of normal dogs without any abnormalities in clinical findings, blood exams or diagnostic imaging. The correlation of P-AMY with cPL was confirmed by Pearson's correlation analysis (r = 0.564, p &lt; .001). The sensitivity and specificity for the most appropriate cut-off values of P-AMY were recorded similar to the values of DGGR. The dogs with AP and CAPS ≥11 had significantly higher serum P-AMY (p = .016) contrary to DGGR lipase and cPL. Furthermore, there was a significant difference in the median P-AMY dependent on the presence of systemic inflammatory response syndrome (p = .001). P-AMY showed similar level of diagnostic accuracy along with sensitivity and specificity compared to DGGR lipase. In addition, P-AMY showed a significant association with CAPS score, contrary to cPL and DGGR lipase. Along with other biomarkers associated with AP, P-AMY has the potential of usefulness as a supportive diagnostic and prognostic biomarker of AP in dogs.</abstract><cop>England</cop><pub>Taylor &amp; Francis</pub><pmid>38497337</pmid><doi>10.1080/01652176.2024.2326007</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
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source Taylor & Francis Open Access; Publicly Available Content Database; PubMed Central
subjects Abnormalities
Acute pancreatitis
Amylases
Biomarkers
Correlation analysis
Diagnostic systems
Dogs
Inflammation
Inflammatory response
Lipase
Pancreas
pancreatic-alpha amylase
Pancreatitis
Sensitivity analysis
Systemic inflammatory response syndrome
Veterinary medicine
α-Amylase
title Evaluation of the clinical usefulness of pancreatic alpha amylase as a novel biomarker in dogs with acute pancreatitis: a pilot study
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