Photoelectrochemical sensing of isoniazid and streptomycin based on metal Bi-doped BiOI microspheres grown on book-shape layers of Ti 3 C 2 heterostructures

• Published in: Mikrochimica acta (1966) 2024-04, Vol.191 (5), p.260
• Main Authors: Ding, Chengzhi, Ma, Shengnan, Wang, Shuohao, Liang, Ruixia, Liu, Yuanyuan, Wang, Wei, Chen, Huihui, Guo, Xufeng, Wang, Jiao, Wei, Li
• Format: Article
• Language: English
• Subjects: Isoniazid; Metals; Microspheres; Oligonucleotides; Streptomycin; Titanium
• ISSN: 1436-5073
• DOI: 10.1007/s00604-024-06280-w

Isoniazid and streptomycin are vital drugs for treating tuberculosis, which are utilized as efficient anti-tuberculosis agents. This paper presents a novel visible-light-driven composite photocatalyst Ti C /Bi/BiOI, which was built from Ti C nanosheets and Bi/BiOI microspheres. Photoelectrochemical (PEC) sensors based on Ti C /Bi/BiOI were synthesized for isoniazid identification, which showed a linear concentration range of 0.1-125 μM with a detection limit of 0.05 μM (S/N = 3). Moreover, we designed a PEC aptasensors based on aptamer/Ti C /Bi/BiOI to detect streptomycin in 0.1 M PBS covering the electron donor isoniazid, because the isoniazid consumes photogenerated holes thus increasing the photocurrent effectively and preventing photogenerated electron-hole pairs from being recombined. Furthermore, PEC aptasensors based on aptamer/Ti C /Bi/BiOI were synthesized for streptomycin identification, which exhibited a linear concentration range of 0.01-1000 nM with a detection limit of 2.3 × 10 nM (S/N = 3), and are well stable in streptomycin sensing.