Maximum tumor diameter and renal function can predict the declining surface dose rate after 177 Lu-Dotatate: preliminary results of single institution in Japan

This study aimed to develop a user-friendly prediction formula for dose rate adjustment after initial Lu-Dotatate therapy from a prospective observational study of patients. This study included consenting patients in a prospective observational study who underwent their first treatment in four cycle...

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Bibliographic Details
Published in:Japanese journal of radiology 2024-09, Vol.42 (9), p.1031
Main Authors: Ono, Takashi, Ichikawa, Mayumi, Tanada, Takeo, Kanezawa, Chika, Sato, Hiraku
Format: Article
Language:English
Subjects:
Adult
Aged
Female
Humans
Japan
Kidney - diagnostic imaging
Kidney - pathology
Kidney Function Tests - methods
Male
Middle Aged
Neuroendocrine Tumors - diagnostic imaging
Neuroendocrine Tumors - radiotherapy
Octreotide - administration & dosage
Octreotide - analogs & derivatives
Octreotide - therapeutic use
Organometallic Compounds - administration & dosage
Organometallic Compounds - therapeutic use
Prospective Studies
Radiopharmaceuticals - therapeutic use
Radiotherapy Dosage
Tumor Burden
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Summary:This study aimed to develop a user-friendly prediction formula for dose rate adjustment after initial Lu-Dotatate therapy from a prospective observational study of patients. This study included consenting patients in a prospective observational study who underwent their first treatment in four cycles of Lu-Dotatate treatment at our hospital between January 2022 and February 2024. All patients received 7.4 GBq of Lu-Dotatate. The prediction formula was derived from the regression analysis of tumor-related factors and renal function. Creatinine clearance was estimated using the Cockcroft-Gault equation in this study for renal function. Among the 13 patients (seven males, six females, median age: 59 years), logarithmically transformed total tumor volume (cc) and maximum tumor diameter (mm) of primary tumors or metastases showed strong correlations (p 
ISSN:1867-108X