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Reversal of γ-Radiation-Induced Leukemogenesis in Mice by Immunomodulation with Thiabendazole and Dinitrofluorobenzene
The effect of thiabendazole (TBZ) and dinitrofluorobenzene (DNFB) on radiation-induced leukemogenesis was investigated in the C57BL/6 mouse model. Administration of TBZ-DNFB during, post, or during and post irradiation successfully blocked leukemogenesis, as indicated by the absence of leukemia blas...
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| Published in: | JNCI : Journal of the National Cancer Institute 1985-04, Vol.74 (4), p.811-815 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 815 |
| container_issue | 4 |
| container_start_page | 811 |
| container_title | JNCI : Journal of the National Cancer Institute |
| container_volume | 74 |
| creator | Eigebaly, Salwa A. Barton, Randall Forouhar, Faripour |
| description | The effect of thiabendazole (TBZ) and dinitrofluorobenzene (DNFB) on radiation-induced leukemogenesis was investigated in the C57BL/6 mouse model. Administration of TBZ-DNFB during, post, or during and post irradiation successfully blocked leukemogenesis, as indicated by the absence of leukemia blast cells in thymus and peripheral blood, as well as prevented thymic lymphoma. TBZ-DNFB treatment prevented the development of leukemia when studies were terminated both after 7 months of last irradiation (disease fully developed) and after 5 months of last irradiation (disease in the process of development). This TBZ-DNFB treatment also resulted in a significant increase in survival. |
| doi_str_mv | 10.1093/jnci/74.4.811 |
| format | article |
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Administration of TBZ-DNFB during, post, or during and post irradiation successfully blocked leukemogenesis, as indicated by the absence of leukemia blast cells in thymus and peripheral blood, as well as prevented thymic lymphoma. TBZ-DNFB treatment prevented the development of leukemia when studies were terminated both after 7 months of last irradiation (disease fully developed) and after 5 months of last irradiation (disease in the process of development). This TBZ-DNFB treatment also resulted in a significant increase in survival.</description><identifier>ISSN: 0027-8874</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/74.4.811</identifier><identifier>PMID: 3872957</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Animals ; Antineoplastic agents ; Biological and medical sciences ; Dinitrofluorobenzene - administration & dosage ; Dinitrofluorobenzene - therapeutic use ; Drug Therapy, Combination ; Gamma Rays ; General aspects ; Immunotherapy ; Leukemia, Radiation-Induced - chemically induced ; Leukemia, Radiation-Induced - immunology ; Leukemia, Radiation-Induced - prevention & control ; Longevity - drug effects ; Lymphoma - etiology ; Lymphoma - immunology ; Lymphoma - prevention & control ; Male ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Nitrobenzenes - administration & dosage ; Organ Size - drug effects ; Pharmacology. 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Administration of TBZ-DNFB during, post, or during and post irradiation successfully blocked leukemogenesis, as indicated by the absence of leukemia blast cells in thymus and peripheral blood, as well as prevented thymic lymphoma. TBZ-DNFB treatment prevented the development of leukemia when studies were terminated both after 7 months of last irradiation (disease fully developed) and after 5 months of last irradiation (disease in the process of development). This TBZ-DNFB treatment also resulted in a significant increase in survival.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Dinitrofluorobenzene - administration & dosage</subject><subject>Dinitrofluorobenzene - therapeutic use</subject><subject>Drug Therapy, Combination</subject><subject>Gamma Rays</subject><subject>General aspects</subject><subject>Immunotherapy</subject><subject>Leukemia, Radiation-Induced - chemically induced</subject><subject>Leukemia, Radiation-Induced - immunology</subject><subject>Leukemia, Radiation-Induced - prevention & control</subject><subject>Longevity - drug effects</subject><subject>Lymphoma - etiology</subject><subject>Lymphoma - immunology</subject><subject>Lymphoma - prevention & control</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Nitrobenzenes - administration & dosage</subject><subject>Organ Size - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>T-Lymphocytes - drug effects</subject><subject>T-Lymphocytes - radiation effects</subject><subject>Thiabendazole - administration & dosage</subject><subject>Thiabendazole - therapeutic use</subject><subject>Thymus Gland - drug effects</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><recordid>eNo9kMtKxDAUhoMoOl6WLoUs3HbMpZmkSxkvM1ARhxEGNyVtTjTaJtK0jvpavofPZNHBw4Gz-L7zL36EjikZU5Lxs2dfuTOZjtOxonQLjWg6IQmjRGyjESFMJkrJdA_tx_hMhslYuot2uZIsE3KE1gt4gzbqGgeLv7-ShTZOdy74ZO5NX4HBOfQv0IRH8BBdxM7jG1cBLj_wvGl6H5pg-vr3Ba9d94SXT06X4I3-DDVg7Q2-cN51bbB1H9owoM8h6hDtWF1HONrcA3R_dbmczpL89no-Pc8TxyTvEpCy0owJSoAqWylF02FtSYCbrJwIaa0tUyulSQkrpQEuFNUUSpCZpkzxA3Tyl_valw2Y4rV1jW4_ik0BAz_dcB0rXdtWD3XGf00JISaKD1ryp7nYwfs_1u1LMZFcimK2eijodLWc5XcPRc5_AM4OfMg</recordid><startdate>198504</startdate><enddate>198504</enddate><creator>Eigebaly, Salwa A.</creator><creator>Barton, Randall</creator><creator>Forouhar, Faripour</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>198504</creationdate><title>Reversal of γ-Radiation-Induced Leukemogenesis in Mice by Immunomodulation with Thiabendazole and Dinitrofluorobenzene</title><author>Eigebaly, Salwa A. ; Barton, Randall ; Forouhar, Faripour</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i273t-e77ca22510e18fc8814814fb0e3d9b657fffb4f77d402b7de3581a1ebe79a1283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Dinitrofluorobenzene - administration & dosage</topic><topic>Dinitrofluorobenzene - therapeutic use</topic><topic>Drug Therapy, Combination</topic><topic>Gamma Rays</topic><topic>General aspects</topic><topic>Immunotherapy</topic><topic>Leukemia, Radiation-Induced - chemically induced</topic><topic>Leukemia, Radiation-Induced - immunology</topic><topic>Leukemia, Radiation-Induced - prevention & control</topic><topic>Longevity - drug effects</topic><topic>Lymphoma - etiology</topic><topic>Lymphoma - immunology</topic><topic>Lymphoma - prevention & control</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Nitrobenzenes - administration & dosage</topic><topic>Organ Size - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>T-Lymphocytes - drug effects</topic><topic>T-Lymphocytes - radiation effects</topic><topic>Thiabendazole - administration & dosage</topic><topic>Thiabendazole - therapeutic use</topic><topic>Thymus Gland - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eigebaly, Salwa A.</creatorcontrib><creatorcontrib>Barton, Randall</creatorcontrib><creatorcontrib>Forouhar, Faripour</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eigebaly, Salwa A.</au><au>Barton, Randall</au><au>Forouhar, Faripour</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reversal of γ-Radiation-Induced Leukemogenesis in Mice by Immunomodulation with Thiabendazole and Dinitrofluorobenzene</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>Journal of the National Cancer Institute</addtitle><date>1985-04</date><risdate>1985</risdate><volume>74</volume><issue>4</issue><spage>811</spage><epage>815</epage><pages>811-815</pages><issn>0027-8874</issn><eissn>1460-2105</eissn><abstract>The effect of thiabendazole (TBZ) and dinitrofluorobenzene (DNFB) on radiation-induced leukemogenesis was investigated in the C57BL/6 mouse model. Administration of TBZ-DNFB during, post, or during and post irradiation successfully blocked leukemogenesis, as indicated by the absence of leukemia blast cells in thymus and peripheral blood, as well as prevented thymic lymphoma. TBZ-DNFB treatment prevented the development of leukemia when studies were terminated both after 7 months of last irradiation (disease fully developed) and after 5 months of last irradiation (disease in the process of development). This TBZ-DNFB treatment also resulted in a significant increase in survival.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>3872957</pmid><doi>10.1093/jnci/74.4.811</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8874 |
| ispartof | JNCI : Journal of the National Cancer Institute, 1985-04, Vol.74 (4), p.811-815 |
| issn | 0027-8874 1460-2105 |
| language | eng |
| recordid | cdi_pubmed_primary_3872957 |
| source | Oxford University Press:Jisc Collections:Oxford Journal Archive: Access period 2024-2025 |
| subjects | Animals Antineoplastic agents Biological and medical sciences Dinitrofluorobenzene - administration & dosage Dinitrofluorobenzene - therapeutic use Drug Therapy, Combination Gamma Rays General aspects Immunotherapy Leukemia, Radiation-Induced - chemically induced Leukemia, Radiation-Induced - immunology Leukemia, Radiation-Induced - prevention & control Longevity - drug effects Lymphoma - etiology Lymphoma - immunology Lymphoma - prevention & control Male Medical sciences Mice Mice, Inbred C57BL Nitrobenzenes - administration & dosage Organ Size - drug effects Pharmacology. Drug treatments T-Lymphocytes - drug effects T-Lymphocytes - radiation effects Thiabendazole - administration & dosage Thiabendazole - therapeutic use Thymus Gland - drug effects |
| title | Reversal of γ-Radiation-Induced Leukemogenesis in Mice by Immunomodulation with Thiabendazole and Dinitrofluorobenzene |
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