Effect of Orally Ingested Water Containing H 2 -Filled Ultrafine Bubbles (UFBs) on Ethanol-Induced Oxidative Stress in Rats

Ultrafine bubbles (UFBs), which are bubbles with diameters of less than 1 µm, are widely recognized for their ability to exist stably in liquid as a result of the effects of Brownian motion. In this study, we focused on hydrogen, known for its antioxidant potential, and explored the function of H -f...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2024, Vol.47 (6), p.1106
Main Authors: Morishita, Risako, Onishi, Ayaka, Oya, Maresuke, Karashima, Hirotsugu, Mori, Misato, Kawatani, Yuka, Kamei, Noriyasu, Takeda-Morishita, Mariko
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Antioxidants - administration & dosage
Antioxidants - pharmacology
Ethanol - administration & dosage
Hydrogen - administration & dosage
Hydrogen - pharmacology
Lipid Peroxidation - drug effects
Liver - drug effects
Liver - metabolism
Male
Oxidative Stress - drug effects
Rats
Rats, Wistar
Water
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Summary:Ultrafine bubbles (UFBs), which are bubbles with diameters of less than 1 µm, are widely recognized for their ability to exist stably in liquid as a result of the effects of Brownian motion. In this study, we focused on hydrogen, known for its antioxidant potential, and explored the function of H -filled UFBs, which encapsulate hydrogen, to determine their potential use as oral carriers for the delivery bioactive gases to living organisms. To this end, rats were orally administered ethanol to induce hepatic oxidative stress, and the effects of drinking H -filled UFBs (H NanoGAS ) water for two weeks were evaluated to assess the reduction of oxidative stress. Continuous alcohol consumption was found to significantly increase the blood lipid peroxidation levels in the control group, confirming the induction of oxidative stress. An increase in blood lipid peroxidation was significantly inhibited by the consumption of concentrated H NanoGAS (C-HN) water. Furthermore, the measurement of mitochondrial activity in the liver revealed that drinking H NanoGAS water helped to maintain at a normal level and/or boosted the functional activity of the electron transport system in mitochondria affected by ethanol intake. To our knowledge, this study is the first to provide evidence for the use of orally ingested UFBs as carriers for the delivery gases to tissues, thereby exerting their physiological activity in the body. Our findings highlight the potential for the application of UFBs to various physiologically active gases and their utilization in the medical field in the future.
ISSN:1347-5215