A dual-signaling surface-enhanced Raman spectroscopy ratiometric strategy for ultrasensitive Hg 2+ detection based on Au@Ag/COF composites

Heavy metal ion pollution poses significant risks to human health and ecological systems, and its monitoring is important. A sensitive and accurate surface-enhanced Raman spectroscopy (SERS) detection assay for Hg was developed using Au@Ag/COF substrates and Y-shaped DNA labeled with two Raman repor...

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Bibliographic Details
Published in:Food chemistry 2024-06, Vol.456, p.139998
Main Authors: Li, Yuanyuan, Zhou, Na, Yan, Jiayu, Cui, Kaixin, Chu, Qiqi, Chen, Xi, Luo, Xiaojun, Deng, Xiaojun
Format: Article
Language:English
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Summary:Heavy metal ion pollution poses significant risks to human health and ecological systems, and its monitoring is important. A sensitive and accurate surface-enhanced Raman spectroscopy (SERS) detection assay for Hg was developed using Au@Ag/COF substrates and Y-shaped DNA labeled with two Raman reporters. The Au@Ag NPs in the COF produced robust and uniform E-fields, improving their detection reproducibility. The Y-shaped DNA design increased sensitivity with a low detection limit of 5.0 × 10  M by bringing the Raman reporter closer to the substrate surface. Additionally, the use of two Raman reporters allowed for a ratiometric method, improving detection accuracy by detecting both "signal-off" and "signal-on" signals. This selective sensor exhibited excellent recovery in river water, tap water, and milk samples, showcasing its robust biosensing capability for the detection of Hg and its potential for sensing other heavy-metal ions in food and environmental applications.
ISSN:1873-7072