Silver incorporated SeTe nanoparticles with enhanced photothermal and photodynamic properties for synergistic effects on anti-bacterial activity and wound healing

Bacteria invade the host's immune system, thereby inducing serious infections. Current treatments for bacterial infections mostly rely on single modalities, which cannot completely inhibit bacteria. This study evaluates the therapeutic potential of SeTe-Ag NPs, designed with excellent photo res...

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Bibliographic Details
Published in:RSC advances 2024-06, Vol.14 (27), p.18871-18878
Main Authors: Ullah, Irfan, Khan, Shahin Shah, Ahmad, Waqar, Liu, Luo, Rady, Ahmed, Aldahmash, Badr, Yu, Changyuan, Wang, Yushu
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Bacteria
Biomedical materials
Chemistry
Immune system
Nanoparticles
Near infrared radiation
Synergistic effect
Wound healing
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Summary:Bacteria invade the host's immune system, thereby inducing serious infections. Current treatments for bacterial infections mostly rely on single modalities, which cannot completely inhibit bacteria. This study evaluates the therapeutic potential of SeTe-Ag NPs, designed with excellent photo responsiveness, with a particular focus on their dual-action antibacterial effect and wound healing properties. SeTe-Ag NPs exhibited promising synergistic antibacterial effects due to their superior photothermal and photodynamic properties. The investigation records substantial zones of inhibition of bacteria, demonstrating potent antibacterial effect. Furthermore, upon the irradiation of near-infrared (NIR) light, SeTe-Ag NPs exhibit remarkable antibiofilm and wound-healing capabilities. Overall, this study shows the applications of NIR-active SeTe-Ag NPs, which serve as a versatile platform for biomedical applications. Synthesis of SeTe-Ag NPs with excellent photothermal and photodynamic properties for bacterial infection and wound healing therapy.
ISSN:2046-2069
2046-2069
DOI:10.1039/d4ra01343c