Application of a calcium and phosphorus biomineralization strategy in tooth repair: a systematic review

Biomineralization is a natural process in which organisms regulate the growth of inorganic minerals to form biominerals with unique layered structures, such as bones and teeth, primarily composed of calcium and phosphorus. Tooth decay significantly impacts our daily lives, and the key to tooth regen...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2024-08, Vol.12 (33), p.833-847
Main Authors: Dong, Haide, Wang, Danyang, Deng, Hanyue, Yin, Lijuan, Wang, Xiongying, Yang, Weihu, Cai, Kaiyong
Format: Article
Language:English
Subjects:
Animals
Biomimetic materials
Biomimetics
Biomineralization
Bones
Calcium
Calcium - metabolism
Humans
Mineral exploration
Mineralization
Minerals
Phosphorus
Phosphorus - chemistry
Reviews
Teeth
Tooth - chemistry
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Summary:Biomineralization is a natural process in which organisms regulate the growth of inorganic minerals to form biominerals with unique layered structures, such as bones and teeth, primarily composed of calcium and phosphorus. Tooth decay significantly impacts our daily lives, and the key to tooth regeneration lies in restoring teeth through biomimetic approaches, utilizing mineralization strategies or materials that mimic natural processes. This review delves into the types, properties, and transformations of calcium and phosphorus minerals, followed by an exploration of the mechanisms behind physiological and pathological mineralization in living organisms. It summarizes the mechanisms and commonalities of biomineralization and discusses the advancements in dental biomineralization research, guided by insights into calcium and phosphorus mineral biomineralization. This review concludes by addressing the current challenges and future directions in the field of dental biomimetic mineralization. This review summarizes the mechanisms and commonalities of biomineralization and discusses the advancements in dental biomineralization research, guided by insights into calcium and phosphorus mineral biomineralization.
ISSN:2050-750X
2050-7518
2050-7518
DOI:10.1039/d4tb00867g