Anemia, Iron Deficiency, and Cause-Specific Mortality: The Atherosclerosis Risk in Communities Study

Abstract Introduction: Anemia is a risk factor for all-cause mortality in older adults. Iron deficiency may also be associated with adverse outcomes, independent of its role in causing anemia. This study tested the hypotheses that anemia, and low ferritin among non-anemic participants, were associat...

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Published in:Gerontology (Basel) 2024-10, Vol.70 (10), p.1023-1032
Main Authors: Cannon, Ethan J., Misialek, Jeffrey R., Buckley, Leo F., Aboelsaad, Iman A.F., Ballantyne, Christie M., Leister, John, Pankow, James S., Lutsey, Pamela L.
Format: Article
Language:English
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Clinical Section: Research Article
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Summary:Abstract Introduction: Anemia is a risk factor for all-cause mortality in older adults. Iron deficiency may also be associated with adverse outcomes, independent of its role in causing anemia. This study tested the hypotheses that anemia, and low ferritin among non-anemic participants, were associated with all-cause and cause-specific mortality in a community-based cohort of older adults. Methods: Fasting blood was obtained from 5,070 ARIC participants (median age: 75 years) in 2011–2013. Anemia was defined by hemoglobin concentrations
ISSN:0304-324X
1423-0003
1423-0003
DOI:10.1159/000539973