Baeyer-Villiger oxidation: a promising tool for the synthesis of natural products: a review

Baeyer-Villiger oxidation is a well-known reaction utilized for the synthesis of lactones and ester functionalities from ketones. Chiral lactones can be synthesized from chiral or racemic ketones by employing asymmetric Baeyer-Villiger oxidation. These lactones act as key intermediates in the synthe...

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Bibliographic Details
Published in:RSC advances 2024-07, Vol.14 (32), p.23423-23458
Main Authors: Fatima, Summaya, Zahoor, Ameer Fawad, Khan, Samreen Gul, Naqvi, Syed Ali Raza, Hussain, Syed Makhdoom, Nazeer, Usman, Mansha, Asim, Ahmad, Hamad, Chaudhry, Aijaz Rasool, Irfan, Ahmad
Format: Article
Language:English
Subjects:
Chemical synthesis
Chemistry
Ketones
Lactones
Natural products
Organic chemistry
Oxidation
Oxidizing agents
Terpenes
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Summary:Baeyer-Villiger oxidation is a well-known reaction utilized for the synthesis of lactones and ester functionalities from ketones. Chiral lactones can be synthesized from chiral or racemic ketones by employing asymmetric Baeyer-Villiger oxidation. These lactones act as key intermediates in the synthesis of most of the biologically active natural products, their analogues, and derivatives. Various monooxygenases and oxidizing agents facilitate BV oxidation, providing a broad range of synthetic applications in organic chemistry. The variety of enzymatic and chemoselective Baeyer-Villiger oxidations and their substantial role in the synthesis of natural products i.e. , alkaloids, polyketides, fatty acids, terpenoids, etc. (reported since 2018) have been summarized in this review article. Baeyer-Villiger oxidation is a renowned reaction that provides an efficient route for the synthesis of biologically active natural products such as alkaloids, terpenoids, polyketides and fatty acid-based naturally occurring organic compounds.
ISSN:2046-2069
2046-2069
DOI:10.1039/d4ra03914a