De Novo Genes

Although the majority of annotated new genes in a given genome appear to have arisen from duplication-related mechanisms, recent studies have shown that genes can also originate de novo from ancestrally nongenic sequences. Investigating de novo–originated genes offers rich opportunities to understan...

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Bibliographic Details
Published in:Annual review of genetics 2024-11, Vol.58 (1), p.211-232
Main Authors: Zhao, Li, Svetec, Nicolas, Begun, David J
Format: Article
Language:English
Subjects:
adaptive evolution
Animals
de novo proteins
Evolution, Molecular
Evolutionary genetics
Gene Duplication
gene gain
gene loss
Gene sequencing
Genes
Genome - genetics
Genomics - methods
Humans
regulation of expression
Regulatory mechanisms (biology)
small ORFs
Citations: Items that this one cites
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Summary:Although the majority of annotated new genes in a given genome appear to have arisen from duplication-related mechanisms, recent studies have shown that genes can also originate de novo from ancestrally nongenic sequences. Investigating de novo–originated genes offers rich opportunities to understand the origin and functions of new genes, their regulatory mechanisms, and the associated evolutionary processes. Such studies have uncovered unexpected and intriguing facets of gene origination, offering novel perspectives on the complexity of the genome and gene evolution. In this review, we provide an overview of the research progress in this field, highlight recent advancements, identify key technical and conceptual challenges, and underscore critical questions that remain to be addressed.
ISSN:0066-4197
1545-2948
1545-2948
DOI:10.1146/annurev-genet-111523-102413