Antibiotic Nanoparticles-Loaded Wound Dressings Against Pseudomonas aeruginosa 's Skin Infection: A Systematic Review

( ) is a common nosocomial pathogen that can cause severe infections in critically ill patients. Due to its resistance to multiple drugs, it is challenging to treat, which can result in serious illness and death. Conventional treatments for infected wounds often involve the topical or systemic appli...

Full description

Saved in:
Bibliographic Details
Published in:International journal of nanomedicine 2024, Vol.19, p.7895
Main Authors: Quiñones-Vico, María I, Ubago-Rodríguez, Ana, Fernández-González, Ana, Sanabria-de la Torre, Raquel, Sierra-Sánchez, Álvaro, Montero-Vilchez, Trinidad, Sánchez-Díaz, Manuel, Arias, José L, Arias-Santiago, Salvador
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Bandages
Humans
Metal Nanoparticles - chemistry
Nanoparticles - chemistry
Pseudomonas aeruginosa - drug effects
Pseudomonas Infections - drug therapy
Silver - administration & dosage
Silver - chemistry
Silver - pharmacology
Wound Healing - drug effects
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:( ) is a common nosocomial pathogen that can cause severe infections in critically ill patients. Due to its resistance to multiple drugs, it is challenging to treat, which can result in serious illness and death. Conventional treatments for infected wounds often involve the topical or systemic application of antibiotics, which can lead to systemic toxicity and the development of drug resistance. The combination of wound dressings that promote wound healing with nanoparticles (NPs) represents a revolutionary strategy for optimizing the safety and efficacy of antibiotics. This review assesses a systematic search to identify the latest approaches where the evaluation of wound dressings loaded with antibiotic NPs is conducted. The properties of NPs, the features of wound dressings, the antimicrobial activity and biocompatibility of the different strategies are analyzed. The results indicate that most research in this field is focused on dressings loaded with silver NPs (57.1%) or other inorganic materials (22.4%). Wound dressings loaded with polymeric NPs and carbon-based NPs represent 14.3% and 6.1% of the evaluated studies, respectively. Nevertheless, there are no clinical trials that have evaluated the efficacy of NPs-loaded wound dressings in patients. Further research is required to ensure the safety of these treatments and to translate the findings from the bench to the bedside.
ISSN:1178-2013