Porous calcium silicate bioactive material-alginate composite for bone regeneration

Bone tissue engineering aims to address bone-related problems that arise from trauma, infection, tumors, and surgery. Polymer and calcium silicate bioactive material (BM) based composites are commonly preferred as potential materials for bone treatment. However, the polymer has low bioactivity, thus...

Full description

Saved in:
Bibliographic Details
Published in:RSC advances 2024-08, Vol.14 (35), p.2574-25749
Main Authors: Shendage, Shital S, Kachare, Kranti, Gaikwad, Kajal, Kashte, Shivaji, Ghule, Anil Vithal
Format: Article
Language:English
Subjects:
Biocompatibility
Biological activity
Biomedical materials
Body fluids
Bones
Calcium silicates
Chemistry
Crosslinking
Hemolysis
Hydroxyapatite
In vitro methods and tests
In vivo methods and tests
Polymers
Porous materials
Regeneration (physiology)
Sodium alginate
Tissue engineering
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bone tissue engineering aims to address bone-related problems that arise from trauma, infection, tumors, and surgery. Polymer and calcium silicate bioactive material (BM) based composites are commonly preferred as potential materials for bone treatment. However, the polymer has low bioactivity, thus, the current work aims to prepare a composite scaffold based on BM-sodium alginate (Alg) by varying the Alg percentage to optimize the porous nature of the composite. Primarily, the BM was synthesized by a simple precipitation method using rice husk and eggshell as the precursors of silica and calcium, while the BM-Alg composite was prepared by a facile cross-linking approach. The BM-Alg composite was studied using XRD, FTIR, SEM, and BET techniques. Further, an in vitro bioactivity study was performed in simulated body fluid (SBF) which shows hydroxyapatite formation. The in vitro haemolysis study displayed less than 5% haemolysis. Subsequently, the angiogenesis study was carried out using the ex ovo CAM model which reveals enhanced neovascularization. The MG-63 cells were used to study the biocompatibility, and they displayed a non-toxic nature at a concentration of 10 mg mL −1 . Further, the in vivo biocompatibility results also reveal its non-toxic nature. Thus, the BM-Alg composite acts as a potential biocompatible material for bone tissue engineering applications. A biocompatible, porous, and eco-friendly BM-sodium alginate composite for bone regeneration application.
ISSN:2046-2069
2046-2069
DOI:10.1039/d4ra02763a