Exploring the link between inflammatory myopathies and cancer: A comprehensive retrospective analysis in a Colombian cohort

This study investigates the association between inflammatory myopathies (IM), and their correlation with cancer. There are several potential causes behind the association of cancer and inflammatory myopathies. The positivity of specific antibodies for myositis plays a significant role. Our objective...

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Published in:Reumatología clinica (Barcelona) 2024-08, Vol.20 (7), p.353-359
Main Authors: Bolaños, Juan D., Rivera-Londoño, Robert, Hurtado-Bermúdez, Leidy Johanna, Nieto-Aristizábal, Ivana, Enriquez, Karol D., Zura-Rodríguez, Santiago, Hormaza-Jaramillo, Andrés, Aguirre-Valencia, David
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Cancer
Colombia - epidemiology
Cáncer
Cáncer de tiroides
Dermatomiositis
Dermatomyositis
Dermatomyositis - epidemiology
Female
Humans
Male
Middle Aged
Myositis - epidemiology
Neoplasias
Neoplasms
Neoplasms - epidemiology
Polimiositis
Polymyositis
Retrospective Studies
Risk Factors
Thyroid cancer
Young Adult
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Summary:This study investigates the association between inflammatory myopathies (IM), and their correlation with cancer. There are several potential causes behind the association of cancer and inflammatory myopathies. The positivity of specific antibodies for myositis plays a significant role. Our objective is to describe cancer and inflammatory myopathies in Colombia, focusing on demographics, clinical characteristics, and laboratory data. We retrospectively analyzed 112 IM patients diagnosed at Fundación Valle del Lili in Cali, Colombia, the cases met the EULAR/ACR criteria. Data included demographics, clinical signs, laboratory findings, and malignancy. Malignancy associations were explored using logistic regression. The survival analysis was assessed using Kaplan–Meier curves and the Log-Rank test. Dermatomyositis was the most common subtype (45.5%), with a female predominance (66.1%). Cancer diagnosis occurred in 11.6% of cases, predominantly thyroid cancer. The median time from myopathy onset to cancer diagnosis was 11 months, with 75% of cases within the first year. Bivariate analysis indicated associations between cancer and age, Gottron's papules, digital ulcers, and heliotrope rash. However, multivariate analysis identified age as the only significant malignancy risk factor. Survival analysis showed better rates in younger patients. This study provides into the link between IM and cancer in the Colombian population. Thyroid cancer predominated, with a slightly higher proportion of female cancer diagnoses. Age emerged as a significant risk factor for malignancy. Understanding this association is crucial for early detection and improving patient outcomes related to IM-associated malignancies. Este estudio investiga la asociación entre las miopatías inflamatorias (MI) y su correlación con el cáncer. Hay varias causas potenciales detrás de la asociación entre el cáncer y las miopatías inflamatorias. La positividad de anticuerpos específicos para la miositis desempeña un papel importante. Nuestro objetivo es describir el cáncer y las miopatías inflamatorias en Colombia, centrándonos en datos demográficos, características clínicas y laboratorios. Analizamos retrospectivamente a 112 pacientes de MI diagnosticados en la Fundación Valle del Lili en Cali, Colombia, cuyos casos cumplían con los criterios EULAR/ACR. Incluyeron datos demográficos, signos clínicos, hallazgos de laboratorio y malignidad. Se exploraron las asociaciones con malignidad mediante regresión
ISSN:2173-5743
2173-5743
DOI:10.1016/j.reumae.2024.07.004