Hyperpolarized 129 Xe MRI and spectroscopy of gas exchange abnormalities in chronic hypersensitivity pneumonitis

To evaluate 3D gas-exchange functional imaging characteristics using Xe MRI in a group of study participants with chronic hypersensitivity pneumonitis (CHP) as compared with healthy control participants. In this prospective study, 11 participants with clinical and CT findings of CHP (4M 7F, mean age...

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Bibliographic Details
Published in:Respiratory medicine 2024-11, Vol.234, p.107827
Main Authors: Wulfeck, Madison Kocher, Mummy, David G, Zhang, Shuo, Kadi, Diana, Goins, Stacy, Swaminathan, Aparna, Tighe, Robert M, Driehuys, Bastiaan, Mammarappallil, Joseph G
Format: Article
Language:English
Subjects:
Adult
Aged
Alveolitis, Extrinsic Allergic - diagnosis
Alveolitis, Extrinsic Allergic - diagnostic imaging
Alveolitis, Extrinsic Allergic - physiopathology
Chronic Disease
Female
Humans
Imaging, Three-Dimensional
Magnetic Resonance Imaging - methods
Male
Middle Aged
Prospective Studies
Pulmonary Gas Exchange
Xenon Isotopes
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Summary:To evaluate 3D gas-exchange functional imaging characteristics using Xe MRI in a group of study participants with chronic hypersensitivity pneumonitis (CHP) as compared with healthy control participants. In this prospective study, 11 participants with clinical and CT findings of CHP (4M 7F, mean age 67 ± 6.1 years) as well as 41 healthy subjects (25M 16F, mean age 44 ± 18 years) were enrolled between 2017 and 2022 and underwent Xe MRI. Three-dimensional images of ventilation, interstitial membrane uptake, and RBC transfer were rendered into quantitative 3D maps relative to a healthy reference cohort. In addition, Xe spectroscopy was used to assess the RBC:membrane ratio (RBC:M), the oxygen-dependent RBC chemical shift, and cardiogenically-driven RBC oscillation amplitude. Differences between the CHP participants and healthy subjects were assessed using the two-sample t-test or Wilcoxon rank-sum test as appropriate. CHP participants demonstrated significant differences in 6 parameters (p 
ISSN:1532-3064