A One Health Exploration of Antimicrobial Resistance in E. coli originated from Urban and Rural Lakes Ecosystem

Antimicrobial resistance (AMR) has become one of the most serious threats to One Health. Aquatic environments are an ideal non-clinical AMR reservoir and can act as a key battlefront for tackling the AMR. However, AMR data using the One Health approach remains scarce in aquatic environments worldwid...

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Published in:Letters in applied microbiology 2024-10
Main Authors: Priyanka, Priyanka, Meena, Prem Raj, Raj, Dharma, Mishra, Purnima, Jha, Anand Kumar, Duggirala, K Siddaardha, Dhanokar, Akshay, Kumar, Amit, Rana, Anuj, Singh, Arvind Pratap
Format: Article
Language:English
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Summary:Antimicrobial resistance (AMR) has become one of the most serious threats to One Health. Aquatic environments are an ideal non-clinical AMR reservoir and can act as a key battlefront for tackling the AMR. However, AMR data using the One Health approach remains scarce in aquatic environments worldwide. Here, we extensively assessed AMR in E. coli isolated from urban and rural lake ecosystems using the One Health perspective. A total of 162 E. coli isolates obtained from lakes were tested against 25 antimicrobials using an in-vitro antimicrobial susceptibility testing method. A low (2%) to moderate (45%) drug resistance rate was found for all antimicrobials used in human/veterinary medicine or animal/plant agriculture. However, 50% of E. coli isolates exhibited multidrug resistance to drugs used as last-resorts (chloramphenicol, colistin) or as frontline (nitrofurantoin, sulfamethoxazole, ampicillin, gentamicin) against E. coli infections. In conclusion, the presence of MDR E. coli strains in urban or rural lake ecosystems highlights their possible role as AMR reservoirs with potential One Health risks.
ISSN:1472-765X