Modulating the photolysis of aryl azides in a supramolecular host to develop photoactivatable fluorophores

Photolysis of aryl azides is a convenient method to approach more functionalized systems in chemical biology. Here, we present a set of photoactivatable aryl azides that undergo controlled reaction pathways within the cucurbit[7]uril (CB7) cavity upon photolysis. The fluorescence turn-on process is...

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Published in:Chemical communications (Cambridge, England) England), 2024-11, Vol.6 (88), p.12856-12859
Main Authors: Qiu, Xujun, Pohl, Eric, Jung, André, Cai, Qianyu, Su, Haopu, Fuhr, Olaf, Schepers, Ute, Bräse, Stefan
Format: Article
Language:English
Subjects:
Aromatic compounds
Chemical compounds
Medical imaging
Photolysis
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container_end_page 12859
container_issue 88
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container_title Chemical communications (Cambridge, England)
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creator Qiu, Xujun
Pohl, Eric
Jung, André
Cai, Qianyu
Su, Haopu
Fuhr, Olaf
Schepers, Ute
Bräse, Stefan
description Photolysis of aryl azides is a convenient method to approach more functionalized systems in chemical biology. Here, we present a set of photoactivatable aryl azides that undergo controlled reaction pathways within the cucurbit[7]uril (CB7) cavity upon photolysis. The fluorescence turn-on process is utilized for bioimaging. The supramolecular host cucurbit[7]uril selectively directs the photolysis of aryl azides to emissive carbolines, highlighting the potential of developing photoactivatable fluorophores using a host-guest strategy.
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source Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list)
subjects Aromatic compounds
Chemical compounds
Medical imaging
Photolysis
title Modulating the photolysis of aryl azides in a supramolecular host to develop photoactivatable fluorophores
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