Assessment of myco-fabricated Al 2 O 3 NPs toxicity on cancer cells and pathogenic microbes by suppression of bacterial metabolic key enzymes

There has been a recent change in global attention towards addressing antimicrobial resistance (AMR) as a result of the concerning increase in mortality rates. Nanomaterials have become highly favorable options for a wide range of industrial and biological uses. The objective of this study was to pr...

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Bibliographic Details
Published in:International journal of biological macromolecules 2024-12, Vol.283 (Pt 3), p.137073
Main Authors: Hassan, Mervat G, Hamed, Ahmed A, Elmetwalli, Alaa, Abdel-Monem, Mohamed O, El-Shora, Hamed M, Alsallami, Wamedh M
Format: Article
Language:English
Subjects:
Aluminum Oxide - chemistry
Aluminum Oxide - pharmacology
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Aspergillus
Bacteria - drug effects
Cell Line, Tumor
Humans
Metal Nanoparticles - chemistry
Microbial Sensitivity Tests
Nanoparticles - chemistry
Neoplasms - drug therapy
Neoplasms - pathology
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Summary:There has been a recent change in global attention towards addressing antimicrobial resistance (AMR) as a result of the concerning increase in mortality rates. Nanomaterials have become highly favorable options for a wide range of industrial and biological uses. The objective of this study was to produce aluminum oxide nanoparticles (Al O NPs) using a crude extract from the fungus Aspergillus sp. WAH23, and then analyze the nanoparticles using UV-analysis, electron microscopy (TEM and SEM), and (FT-IR) and X-ray diffraction (XRD). Results revealed that formed nanoparticles are spherical with an average size of 8.5 nm. XRD analysis confirmed the crystalline nature of the synthesized Al O NPs. The Al O nanoparticles exhibited antibacterial properties against a wide range of pathogenic microbes. The antibacterial efficacy of these nanoparticles on the examined bacterial strains was exhibited through their ability to hinder several metabolic processes, including phosphofructokinase (PFK), enolase, and glutamine synthetase. Additionally, the nanoparticles increased the activity of NADH-oxidase, the content of MDA, and the formation of H O . The study also examined the anticancer properties of Al O nanoparticles on various types of cancer cells.
ISSN:1879-0003