One-pot synthesis of lactones from ketoacids involving microwave heating and sodium borohydride: application in biomass conversion

A metal-free one-pot cascade method involving NaBH 4 and microwave (MW)-heating efficiently synthesized lactones, including the industrially significant γ-valerolactone at 90% yield. The process directly converts methyl levulinate, succinic acid and a wide range of aliphatic and aromatic ketoacids,...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2024-12, Vol.61 (1), p.93-96
Main Authors: Sharma, Raina, Solanki, Arun Kumar, Jayamurugan, Govindasamy
Format: Article
Language:English
Subjects:
Biomass
Dehydration
Heating
Lactones
Succinic acid
Online Access:Get full text
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Summary:A metal-free one-pot cascade method involving NaBH 4 and microwave (MW)-heating efficiently synthesized lactones, including the industrially significant γ-valerolactone at 90% yield. The process directly converts methyl levulinate, succinic acid and a wide range of aliphatic and aromatic ketoacids, in H 2 O or THF, proceeding via reduction, COOH proton exchange, cyclization, and dehydration, showing promise for biomass conversion. A sustainable, metal-free method using NaBH 4 and microwave heating enables synthesis of a wide range of lactones, including green solvent GVL, via ketoacid reduction, cyclization, and dehydration in water.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d4cc05194g