Hepatoprotective and Antioxidant Activities of LST-02, A Proprietary Herbal Formulation

LST-02 is a proprietary polyherbal formulation prepared by blending 50% standardized hydroethanolic extract of ten well-known herbs, namely Tinospora cordifolia, Phyllanthus amarus, Emblica officinalis, Terminalia chebula, Terminalia bellerica, Azadirachta indica, Adhatoda vasica, Picrorrhiza kurroa...

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Bibliographic Details
Published in:Indian journal of physiology and pharmacology 2015-09, Vol.59 (3), p.322
Main Authors: Sur, Tapas Kumar, Hazra, Avijit
Format: Article
Language:English
Online Access:Get full text
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Summary:LST-02 is a proprietary polyherbal formulation prepared by blending 50% standardized hydroethanolic extract of ten well-known herbs, namely Tinospora cordifolia, Phyllanthus amarus, Emblica officinalis, Terminalia chebula, Terminalia bellerica, Azadirachta indica, Adhatoda vasica, Picrorrhiza kurroa, Swertia chirata and Boerhaavia diffusa. The formulation was evaluated for hepatoprotective and antioxidant properties. The phenolic content and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging abilities were evaluated to ascertain antioxidant property. In vitro hepatoprotective action was examined in carbon tetrachloride (CCl4) challenged isolated rat hepatocytes. Finally, LST-02 pretreatment was examined in D-galactosamine (GalN) induced (200 mg/kg; intraperitoneal) hepatitis in male Wistar rats, with silymarin 25 mg/kg as positive control. In vitro studies confirmed that LST-02 is rich in phenolic compounds. It could inhibited DPPH free radicals and exerted significant (p
ISSN:0019-5499