Defining the role of 2,2',4,4'-tetrabromodiphenyl ether in 3T3-L1 cellular differentiation by transcriptome sequencing analysis

This study aims to investigates the effect of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) on the differentiation of 3T3-L1 cells and its mechanism of action. These 3T3-L1 cells were induced to differentiate in vitro using methylisobutylxanthine, dexamethasone, and insulin conditions, then...

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Bibliographic Details
Published in:Adipocyte 2024-12, Vol.13 (1), p.2430717
Main Authors: Liu, Zao-Ling, Qiayimaerdan, Aerna, Fan, Yong, Jiang, Shu-Rui, Tuerxuna, Zunire, Wang, Meng-Lin, Abudureheman, Haiqiemuhan
Format: Article
Language:English
Subjects:
3T3-L1
3T3-L1 Cells
Adipocytes - cytology
Adipocytes - drug effects
Adipocytes - metabolism
adipogenesis
Adipogenesis - drug effects
Adipogenesis - genetics
Animals
BDE-47
Cell Differentiation - drug effects
Gene Expression Profiling
Halogenated Diphenyl Ethers - pharmacology
Mice
mitosis
Research Paper
Transcriptome
transcriptome sequencing
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Summary:This study aims to investigates the effect of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) on the differentiation of 3T3-L1 cells and its mechanism of action. These 3T3-L1 cells were induced to differentiate in vitro using methylisobutylxanthine, dexamethasone, and insulin conditions, then exposed to either 1% DMSO as a control group or varying concentrations of BDE-47 (2.5 μM, 7.5 μM, 12.5 μM, 18.75 μM, and 25 μM). Oil red O staining showed that the absorbance value of the BDE-47 exposure groups was higher than that of the control group (p 
ISSN:2162-3945
2162-397X
2162-397X
DOI:10.1080/21623945.2024.2430717