Enhancing stability, bioavailability and nutritional intervention effect of procyanidins using bio-based delivery systems: A review

• Published in: International journal of biological macromolecules 2024-12, Vol.287, p.138517
• Main Authors: Tie, Shanshan, Xue, Mengmeng, Chen, Yannan, Wu, Ying, Gu, Shaobin, Tan, Mingqian
• Format: Article
• Language: English
• Subjects: Bioavailability; Delivery system; Nutritional intervention; Procyanidins; Stability
• ISSN: 0141-8130; 1879-0003; 1879-0003
• DOI: 10.1016/j.ijbiomac.2024.138517

Procyanidins (PCs), a kind of polyphenolic compound, have attracted extensive attention due to their strong antioxidant, anti-inflammatory and other activities. However, PCs are susceptible to complex micro-environments, resulting in low stability, poor target tissue delivery and bioavailability, which limits their biological effects. Therefore, it is urgent to find some suitable pathways to protect PCs, avoid their degradation, and maximize their health benefits in nutritional intervention. This review focused on the design and construction of different types of bio-based delivery systems loaded with PCs, such as nanoparticles, microparticles, emulsions, liposomes, hydrogels and fibers. The advantages and biological effects of PCs-based delivery systems in promoting cellular uptake, realizing targeted release of organs, cells and organelles, and even nutritional intervention for different chronic diseases were summarized. Furthermore, the development prospects and challenges of delivery systems in the field of precision nutrition were discussed. The construction of these delivery systems can effectively improve the stability and bioavailability of PCs, and maximize their precise nutritional intervention for various chronic diseases. The design and construction of different types of PCs-based delivery systems, such as nanoparticles, microparticles, emulsions, liposomes, hydrogels and fibers are reviewed for promoting cellular uptake, realizing targeted release and even nutritional intervening in different chronic diseases. [Display omitted] •The multiple challenges faced by PCs in practical application were summarized.•Bio-based delivery systems are ideal carriers for loading and delivering of PCs.•Delivery system can realize targeted and stimuli release of PCs in specific sites.•PCs system has nutritional intervention effects on different chronic diseases.•The stability, bioavailability and bio-effect of PCs were effectively improved.