Loading…

Calculating Apparent p K a Values of Ionizable Lipids in Lipid Nanoparticles

Creating new ionizable lipids for use in lipid nanoparticles (LNPs) is an active field of research. One of the critical properties for selecting suitable ionizable lipids is the apparent p value of the lipid as formulated in an LNP. We have developed a structure-based, computational methodology for...

Full description

Saved in:
Bibliographic Details
Published in:Molecular pharmaceutics 2024-12
Main Authors: Hamilton, Nicholas B, Arns, Steve, Shelley, Mee, Bechis, Irene, Shelley, John C
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Creating new ionizable lipids for use in lipid nanoparticles (LNPs) is an active field of research. One of the critical properties for selecting suitable ionizable lipids is the apparent p value of the lipid as formulated in an LNP. We have developed a structure-based, computational methodology for the prediction of the apparent p value of ionizable lipids within LNPs and have tested it using the lipid formulations in the mRNA LNP COVID-19 vaccines COMIRNATY and Spikevax, and the siRNA LNP therapeutic Onpattro. The calculation was also applied to Lipid A, a variant of the ionizable lipid used in COMIRNATY.
ISSN:1543-8392