How different body compositions affect the prognosis of HCC undergoing immunotherapy: the paradoxical phenomenon of BMI

Body mass index (BMI) is associated with the prognosis of hepatocellular carcinoma (HCC) receiving immunotherapy. Body compositions are considered to account for this association, but this hypothesis has yet to be verified conclusively. Our study included 305 patients received immunotherapy at 3 cen...

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Bibliographic Details
Published in:Radiologia medica 2024-12
Main Authors: Ouyang, Jingzhong, Yang, Yi, Xu, Ying, Wang, Zhengzheng, Zhou, Yanzhao, Zhao, Haitao, Zhao, Hong, Cai, Jianqiang, Ye, Feng, Zhou, Jinxue
Format: Article
Language:English
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Summary:Body mass index (BMI) is associated with the prognosis of hepatocellular carcinoma (HCC) receiving immunotherapy. Body compositions are considered to account for this association, but this hypothesis has yet to be verified conclusively. Our study included 305 patients received immunotherapy at 3 centers between August 2018 and February 2022. We calculated skeletal muscle index (SMI), mean skeletal muscle density (SMD), subcutaneous adipose tissue index (SATI), visceral adipose tissue index (VATI), and visceral to subcutaneous adipose tissue area ratio (VSR) at lumbar 3 level. The influences of BMI and body compositions on overall survival (OS) were comprehensively described. Sarcopenia (Low SMI, HR = 2.203, 95% CI:1.425-3.405, P 
ISSN:1826-6983