Selecting High-Risk Patients With Pediatric Crohn's Disease for Top-Down Anti-TNF as per the 2021 ECCO-ESPGHAN Guidelines: A 5-Year Nationwide Retrospective Analysis From Scotland (2016-2020)

The 2021 ECCO-ESPGHAN guideline on the medical management of pediatric Crohn's disease promotes early risk stratification and top-down anti-TNF for patients deemed high risk of severe disease course. We aimed to objectively assess the risk-benefit profile of the guideline's risk stratifica...

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Bibliographic Details
Published in:Inflammatory bowel diseases 2024-12
Main Authors: Scott, Gregor, Wands, David I F, Wilson, David C, Hansen, Richard, Chalmers, Iain
Format: Article
Language:English
Online Access:Get full text
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Summary:The 2021 ECCO-ESPGHAN guideline on the medical management of pediatric Crohn's disease promotes early risk stratification and top-down anti-TNF for patients deemed high risk of severe disease course. We aimed to objectively assess the risk-benefit profile of the guideline's risk stratification policy and guidance on top-down anti-TNF in a nationwide population-based cohort study. Using a prospectively identified nationwide cohort of all new pediatric patients (
ISSN:1536-4844