Pd-Catalyzed [2 + 2 + 2] Cyclization of Alkyne-cyclohexadienones and O -Akynyl Benzenesulfonamides for Construction of Fused Tricyclic Hydronaphthofurans

A palladium-catalyzed [2 + 2 + 2] cyclization of 1,6-enynes with unsymmetrical alkynes has been successfully accomplished, resulting in the formation of a series of fused tricyclic hydronaphthofurans with high stereo- and regioselectivity in a single step. This reaction demonstrates 100% atomic econ...

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Bibliographic Details
Published in:Journal of organic chemistry 2024-12
Main Authors: Tian, Miaomiao, Ma, Xuxu, Zhang, Tianyun, Chang, Junbiao, Liu, Bingxian
Format: Article
Language:English
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Summary:A palladium-catalyzed [2 + 2 + 2] cyclization of 1,6-enynes with unsymmetrical alkynes has been successfully accomplished, resulting in the formation of a series of fused tricyclic hydronaphthofurans with high stereo- and regioselectivity in a single step. This reaction demonstrates 100% atomic economy and exhibits a broad substrate scope.
ISSN:1520-6904