1,2-Oxidative Trifluoromethylation of Olefin with Ag(O 2 CCF 2 SO 2 F) and O 2 : Synthesis of α-Trifluoromethyl Ketones

A novel and efficient 1,2-oxidative trifluoromethylation of olefins employing Ag(O CCF SO F) as a trifluoromethyl source is described with O as the oxidant, which provides access to a variety of valuable α-trifluoromethyl-substituted ketones. The broad substrate scope, feasibility of large-scale ope...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2024-11, Vol.29 (23)
Main Authors: Zhang, Shengxue, Xiao, Wangchuan, Wu, Jingjing, Wu, Fanhong, Huang, Houjin, Ma, Xiaoyu, Shi, Yafei, Liu, Chao
Format: Article
Language:English
Online Access:Get full text
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Summary:A novel and efficient 1,2-oxidative trifluoromethylation of olefins employing Ag(O CCF SO F) as a trifluoromethyl source is described with O as the oxidant, which provides access to a variety of valuable α-trifluoromethyl-substituted ketones. The broad substrate scope, feasibility of large-scale operation, and derivatization reactions of α-trifluoromethyl ketones demonstrate the promising utility of this protocol.
ISSN:1420-3049