CLINICAL EFFICACY OF AZTREONAM FOR REFRACTORY INFECTIONS IN CHILDREN

Aztreonam (AZT) is the first monobactam antibiotic that has significant activity in vitro against aerobic Gram-negative bacteria but not against Gram-positive or anaerobic bacteria. The agent was used 120-200mg/kg in daily dose to treat 10 hospitalized cases of refractory infections in pediatric fie...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1985/11/25, Vol.38(11), pp.3349-3357
Main Authors: HAMADA, FUMIHIKO, OGURA, HIDEO, KITAMURA, ISAMU, MATSUMOTO, KENJI, ARAKI, KUMIKO, KURAMITSU, MAKOTO, FUJIEDA, MIKIYA, KURASHIGE, TAKANOBU, OGURA, YUKIKO
Format: Article
Language:Japanese
Subjects:
Adolescent
Adult
Age Factors
Aztreonam - pharmacology
Aztreonam - therapeutic use
Bacterial Infections - drug therapy
Bacterial Infections - microbiology
Child
Child, Preschool
Drug Evaluation
Female
Gram-Negative Bacteria - drug effects
Humans
Infant
Male
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Summary:Aztreonam (AZT) is the first monobactam antibiotic that has significant activity in vitro against aerobic Gram-negative bacteria but not against Gram-positive or anaerobic bacteria. The agent was used 120-200mg/kg in daily dose to treat 10 hospitalized cases of refractory infections in pediatric field. There were 3 cases of 1 pneumonia, 4 cases of urinary tract infections, 2 cases of pyogenic meningitis and 1 case of septicemia. Seven aerobic Gram-negative bacteria were isolated from patients and 4 bacteria were eradicated by treatment. Clinical cure was achieved in 8 out of 10 cases without adverse reaction or drug toxicity.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.38.3349