Immunity and Asparaginase Suppression of Tumor Growth

L-Asparaginase (Escherichia coli) was least effective in producing tumor (6C3HED and L5178Y) regression when it was injected at the same time as the tumor cells. The degree of tumor inhibition was increased by delaying the administration of asparaginase. Complete regression and cures were obtained w...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1973-07, Vol.51 (1), p.147-150
Main Authors: Ryan, Wayne L., Curtis, Gary L.
Format: Article
Language:English
Subjects:
Animals
Antilymphocyte Serum - pharmacology
Asparaginase - administration & dosage
Asparaginase - therapeutic use
Cell Line
Escherichia coli - enzymology
Female
Immunity
Immunosuppression
Leukemia, Experimental - immunology
Leukemia, Experimental - therapy
Mice - radiation effects
Mice, Inbred C3H
Mice, Inbred DBA
Neoplasms, Experimental - immunology
Neoplasms, Experimental - therapy
Radiation Effects
Remission, Spontaneous
Time Factors
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Summary:L-Asparaginase (Escherichia coli) was least effective in producing tumor (6C3HED and L5178Y) regression when it was injected at the same time as the tumor cells. The degree of tumor inhibition was increased by delaying the administration of asparaginase. Complete regression and cures were obtained with the more asparaginase-resistant L5178Y tumor by postponing asparaginase treatment For 9 days. Immunity or resistance to a second inoculation of tumor also increased as a result of delaying the asparaginase administration. The increased response to deFerred asparaginase treatment was not seen if the mice were immunosuppressed with ALS or γ-irradiation. Complete regressions with asparaginase in immunosuppressed animals were rare, which suggests that immunity is necessary For the cures observed with asparaginase-susceptible tumor.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/51.1.147