Malignant Melanoma: Specific Immunity Induced by Bacillus Calmette-Guérin in BALB/c Mice

Previous treatment of BALB/c mice with bacillus Calmette-Guérin (BCG) will significantly protect them against intramuscular challenge of S-91 melanoma but not against a mammary carcinoma or a methylcholanthrene-induced sarcoma. Lymphocyte-mediated cytotoxicity studies correlate with in vivo data in...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1974-07, Vol.185 (4145), p.68-69
Main Authors: Faraci, Robert P., Schour, Lionel
Format: Article
Language:English
Subjects:
Albumins
Animals
Antibodies, Bacterial - analysis
Antibodies, Neoplasm - analysis
Antilymphocyte Serum
BCG Vaccine
Carcinoma
Carcinoma - prevention & control
Cell Line
Cytotoxicity
Cytotoxicity Tests, Immunologic
Immunity
Immunology
Lymphocytes
Lymphocytes - immunology
Mammary Neoplasms, Experimental - prevention & control
Melanoma
Melanoma - immunology
Melanoma - prevention & control
Methylcholanthrene
Mice
Mice, Inbred BALB C
Mycobacterium bovis - immunology
Neoplasm Transplantation
Noma
Sarcoma
Sarcoma, Experimental - chemically induced
Sarcoma, Experimental - prevention & control
Transplantation, Homologous
Tumors
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Summary:Previous treatment of BALB/c mice with bacillus Calmette-Guérin (BCG) will significantly protect them against intramuscular challenge of S-91 melanoma but not against a mammary carcinoma or a methylcholanthrene-induced sarcoma. Lymphocyte-mediated cytotoxicity studies correlate with in vivo data in showing that BCG-immune lymphocytes are specifically cytotoxic to S-91 melanoma target cells but not to the carcinoma or sarcoma target cells.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.185.4145.68