Folate antagonists. 3. 2,4-Diamino-6-(heterocyclic)quinazolines, a novel class of antimetabolites with potent antimalarial and antibacterial activity

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Bibliographic Details
Published in:Journal of medicinal chemistry 1972-08, Vol.15 (8), p.827
Main Authors: Elslager, E F, Clarke, J, Werbel, L M, Worth, D F, Davoll, J
Format: Article
Language:English
Subjects:
Amines - chemical synthesis
Animals
Anti-Infective Agents - chemical synthesis
Anti-Infective Agents - therapeutic use
Antimalarials - chemical synthesis
Antimalarials - therapeutic use
Antimetabolites - chemical synthesis
Antimetabolites - therapeutic use
Chagas Disease - drug therapy
Chick Embryo
Chickens
Folic Acid Antagonists - chemical synthesis
Folic Acid Antagonists - therapeutic use
Heterocyclic Compounds - chemical synthesis
Heterocyclic Compounds - therapeutic use
Malaria - drug therapy
Mice
Microbial Sensitivity Tests
Quinazolines - chemical synthesis
Quinazolines - therapeutic use
Structure-Activity Relationship
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ISSN:0022-2623
DOI:10.1021/jm00278a008