The effects of aspirin on the development of the mouse third molar. A potential screening system for weak teratogens

Aspirin is teratogenic at high doses in rodents. A dose related effect is shown at much lower levels in an animal testing system which permits subthreshold effects on development to be measured. This system, which depends on changes in tooth size in the mouse, has advantages in assessing weak or cum...

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Bibliographic Details
Published in:Archives of toxicology 1979-07, Vol.42 (3), p.185
Main Authors: Berry, C L, Nickols, C D
Format: Article
Language:English
Subjects:
Animals
Aspirin - adverse effects
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical - methods
Female
Male
Mice
Mice, Inbred Strains
Molar - drug effects
Molar - growth & development
Teratogens
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Summary:Aspirin is teratogenic at high doses in rodents. A dose related effect is shown at much lower levels in an animal testing system which permits subthreshold effects on development to be measured. This system, which depends on changes in tooth size in the mouse, has advantages in assessing weak or cumulative teratogens.
ISSN:0340-5761