S100 Brain Protein: Correlation with Behavior

The brain-specific acidic protein, S100, in the pyramidal nerve cells of the hippocampus was investigated as a possible correlate to learning during transfer of handedness in rats. The amount of S100 increased during training. Intraventricular injection of antiserum against the S100 protein during t...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1970-12, Vol.67 (4), p.1959-1966
Main Authors: Hyden, Holger, Lange, Paul W.
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antiserum
Behavior, Animal
Biological Sciences: Physiology
Brain Chemistry
Electrophoresis
Fluorescence
Fluorescent Antibody Technique
Gels
Handedness
Hippocampus
Hippocampus - analysis
Hippocampus - cytology
Immune Sera - pharmacology
Learning
Leucine - metabolism
Microscopy, Fluorescence
Nerve Tissue Proteins - analysis
Nerve Tissue Proteins - biosynthesis
Nerve Tissue Proteins - physiology
Neurons
Psychophysiology
Rats
Reversal Learning
Training
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Summary:The brain-specific acidic protein, S100, in the pyramidal nerve cells of the hippocampus was investigated as a possible correlate to learning during transfer of handedness in rats. The amount of S100 increased during training. Intraventricular injection of antiserum against the S100 protein during the course of training prevented the rats from further increases in learned behavior but did not affect motor function in the animals. Antibodies against the S100 protein could be localized after injection by immunofluorescence, in hippocampal structures, penetrating presumably through slight ependymal lesions caused by the injection. By contrast, control animals subjected to the same training and injected with S100 antiserum that had been absorbed with S100 protein or with other antisera against γ -globulins showed no decrease in their ability to learn. The conclusion is that the brain-specific protein, S100, is linked to the learning process, at least within the training used.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.67.4.1959