Interferon-Mediated Oncolysis In Spontaneous Murine Leukemia

Time and dose studies in AKR mice with leukemia confirmed, on a cellular level, our previous observations on interferon-mediated oncolysis. Tumor-selective cytolytic action was demonstrable by electron microscopy within one-half hour aFter the administration of interferon. Direct in vitro cytotoxici...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1972-04, Vol.48 (4), p.1155-1159
Main Authors: Kassel, Robert L., Pascal, Robert R., Vas, Adrienne
Format: Article
Language:English
Subjects:
Animals
Cytotoxicity Tests, Immunologic
Half-Life
Interferons - administration & dosage
Interferons - pharmacology
Leukemia, Experimental - immunology
Leukemia, Experimental - pathology
Lymph Nodes - pathology
Lymphocytes
Mice
Mice, Inbred Strains
Microscopy, Electron
Neoplasms
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Summary:Time and dose studies in AKR mice with leukemia confirmed, on a cellular level, our previous observations on interferon-mediated oncolysis. Tumor-selective cytolytic action was demonstrable by electron microscopy within one-half hour aFter the administration of interferon. Direct in vitro cytotoxicity, by exposure of leukemic lymphocytes to interferon, was not observed. However, passive transFer of cytotoxicity by whole blood or serum From interFeron-treated mice indicated the indirect nature of interferon-mediated oncolysis.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/48.4.1155