DISTRIBUTION OF BLEOMYCIN IN SESAME OIL SUSPENSION IN ORGANS OF RAT WITH MAMMARY CARCINOMA INDUCED BY 7, 12-DIMETHYLBENZ (A) ANTHRACENE AND ITS EFFECT ON THE TUMORS

Distribution of the bleomycin A2 suspended in sesame oil (Oil Bleo Suspension) in rat organs and tumors after the intramuscular administration was investigated by bioassay, the effect of intratumor administration of the suspension on the growth of rat mammary carcinoma induced by 7, 12-dimethylbenz...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1975/12/25, Vol.28(6), pp.753-757
Main Authors: TOMINAGA, TAKESHI, TEI, NORIYUKI, KITAMURA, MASATSUGU, AZUMA, YOSHIKO, HORIBATA, KENKICHI
Format: Article
Language:Japanese
Subjects:
9,10-Dimethyl-1,2-benzanthracene
Animals
Bleomycin - administration & dosage
Bleomycin - metabolism
Bleomycin - therapeutic use
Female
Lung - metabolism
Mammary Neoplasms, Experimental - chemically induced
Mammary Neoplasms, Experimental - drug therapy
Mammary Neoplasms, Experimental - metabolism
Rats
Sesame Oil - administration & dosage
Suspensions
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Summary:Distribution of the bleomycin A2 suspended in sesame oil (Oil Bleo Suspension) in rat organs and tumors after the intramuscular administration was investigated by bioassay, the effect of intratumor administration of the suspension on the growth of rat mammary carcinoma induced by 7, 12-dimethylbenz (a) anthracene was also studied. The oil suspension showed a protracted concentration in either tumor or organ tissues, but showed similar inhibitory effects on rat mammary carcinoma to those by regular bleomycin solution. Further studies should be performed on the effect of bleomycin A5 in sesami oil on mammary carcinoma.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.28.753