Chemotherapy of Spontaneous Leukemia in Germfree AKR Mice

Germfree mice tolerated larger subtoxic doses of cyclophosphamide (CP) than conventional mice. Germfree mice survived long-term CP therapy, without the secondary effects of bacterial infections which appeared in CP-treated conventional mice. Large doses of CP in young AKR mice prevented or deferred...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1970-10, Vol.45 (4), p.677-680
Main Authors: Pollard, Morris, Sharon, Nehama
Format: Article
Language:English
Subjects:
Animals
Cyclophosphamide - administration & dosage
Female
Germ-Free Life - drug effects
Leukemia - drug therapy
Male
Mice
Species Specificity
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Summary:Germfree mice tolerated larger subtoxic doses of cyclophosphamide (CP) than conventional mice. Germfree mice survived long-term CP therapy, without the secondary effects of bacterial infections which appeared in CP-treated conventional mice. Large doses of CP in young AKR mice prevented or deferred the development of spontaneous lymphatic leukemia. Treatment with CP also reversed the effects and lesions of acute leukemia in older AKR mice, with significant prolongation of life.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/45.4.677