Teratologic-neurotoxicologic studies on biglumide (K-2004) and thalidomide

Comparison of the teratogenic and neurotoxic influence of thalidomide with the new hypnosedative preparation Biglumide (K-2004) revealed significant differences. Malformations could be seen only after treatment with thalidomide. Some results concerning the thalidomide-treated group of animals could...

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Bibliographic Details
Published in:Archives of toxicology 1977-06, Vol.37 (2), p.165
Main Authors: Jurecka, W, Lassmann, H, Stockinger, L
Format: Article
Language:ger
Subjects:
Animals
Bone Marrow - drug effects
Bone Marrow - embryology
Bridged Bicyclo Compounds - adverse effects
Bridged-Ring Compounds - adverse effects
Central Nervous System - abnormalities
Cycloheptanes - adverse effects
Female
Ganglia, Spinal - drug effects
Ganglia, Spinal - embryology
Hypnotics and Sedatives - adverse effects
Maternal-Fetal Exchange
Peripheral Nerves - drug effects
Peripheral Nerves - embryology
Pregnancy
Rabbits
Spinal Nerves - drug effects
Spinal Nerves - embryology
Teratogens
Thalidomide - adverse effects
Thalidomide - analogs & derivatives
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Summary:Comparison of the teratogenic and neurotoxic influence of thalidomide with the new hypnosedative preparation Biglumide (K-2004) revealed significant differences. Malformations could be seen only after treatment with thalidomide. Some results concerning the thalidomide-treated group of animals could be interpreted as a retardation of development in the posterior root ganglia.
ISSN:0340-5761