Induction of Bladder Tumors and Other Malignancies in Rats With 2-Methoxy-3-Aminodibenzofuran

When fed for a maximum of 75 weeks at a level of 0.1% in the diet, 2-methoxy-3-aminodibenzofuran induced malignant or benign neoplastic changes of the bladder transitional cells in 41.7% of 72 rats. Eleven of these (15.3%) had transitional cell carcinomas. 2-Methoxy-3-aminodibenzofuran also induced...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1967-12, Vol.39 (6), p.1069-1080
Main Authors: Radomski, Jack L., Brill, Earl, Glass, Elliot M.
Format: Article
Language:English
Subjects:
Animals
Benzofurans - administration & dosage
Benzofurans - chemical synthesis
Ear Neoplasms - chemically induced
Female
Kidney Neoplasms - chemically induced
Male
Mammary Neoplasms, Experimental - chemically induced
Neoplasms, Experimental - chemically induced
Rats
Urinary Bladder Neoplasms - chemically induced
Urinary Bladder Neoplasms - pathology
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Summary:When fed for a maximum of 75 weeks at a level of 0.1% in the diet, 2-methoxy-3-aminodibenzofuran induced malignant or benign neoplastic changes of the bladder transitional cells in 41.7% of 72 rats. Eleven of these (15.3%) had transitional cell carcinomas. 2-Methoxy-3-aminodibenzofuran also induced mammary adenocarcinomas and tumors in the external auditory canal. There was little difference in carcinogenicity of the compound in the Sprague-Dawley, Wistar, or Fischer strains. One instance of metastasis of a transitional cell carcinoma to the kidney end lung was observed. The synthesis, purification, and chromatographic characteristics of 2-methoxy-3-aminodibenzofuran are given.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/39.6.1069