Electrical Synapses between Motoneurons in the Spinal Cord of the Newborn Rat

Ventral roots of the newborn rat spinal cord were stimulated while recording intracellularly from motoneurons. In many cells, stimulation subthreshold for an antidromic action potential in the impaled cell produced a small, short-latency depolarization, which was unaffected by membrane polarization....

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Published in:Proceedings of the Royal Society of London. Series B, Biological sciences Biological sciences, 1980-06, Vol.208 (1170), p.115-120
Main Authors: Fulton, Barbara P., Miledi, Ricardo, Takahashi, T.
Format: Article
Language:English
Subjects:
Action potentials
Animals
Animals, Newborn
Axons
Cats
Depolarization
Electric Conductivity
Electrodes
Membrane potential
Motor Neurons - physiology
Rats
Spinal cord
Spinal Cord - physiology
Spinal Nerve roots
Synapses
Synapses - physiology
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cited_by cdi_FETCH-LOGICAL-c607t-c9d6620ce189d8c5018d09894ca209bc9f711a1c6d088047bee123e470209c4f3
cites cdi_FETCH-LOGICAL-c607t-c9d6620ce189d8c5018d09894ca209bc9f711a1c6d088047bee123e470209c4f3
container_end_page 120
container_issue 1170
container_start_page 115
container_title Proceedings of the Royal Society of London. Series B, Biological sciences
container_volume 208
creator Fulton, Barbara P.
Miledi, Ricardo
Takahashi, T.
description Ventral roots of the newborn rat spinal cord were stimulated while recording intracellularly from motoneurons. In many cells, stimulation subthreshold for an antidromic action potential in the impaled cell produced a small, short-latency depolarization, which was unaffected by membrane polarization. This response (antidromic synaptic potential, a.s.p.) was also seen, in some cells, on stimulating the ventral root of an adjacent segment. Replacement of Ca2+ (2 mM) with Mn2+ (3 mM ) or Mg2+ (10 mM) completely abolished orthodromic synaptic potentials, but the a.s.p. persisted. These results strongly suggest that the a.s.p. is produced by an electrical interaction between motoneurons.
doi_str_mv 10.1098/rspb.1980.0045
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identifier ISSN: 0962-8452
ispartof Proceedings of the Royal Society of London. Series B, Biological sciences, 1980-06, Vol.208 (1170), p.115-120
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source JSTOR Archival Journals and Primary Sources Collection【Remote access available】; Royal Society Publishing Jisc Collections Royal Society Journals Read & Publish Transitional Agreement 2025 (reading list)
subjects Action potentials
Animals
Animals, Newborn
Axons
Cats
Depolarization
Electric Conductivity
Electrodes
Membrane potential
Motor Neurons - physiology
Rats
Spinal cord
Spinal Cord - physiology
Spinal Nerve roots
Synapses
Synapses - physiology
title Electrical Synapses between Motoneurons in the Spinal Cord of the Newborn Rat
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