Kinetics and metabolism of a new fluoropyrimidine, 5'-deoxy-5-fluorouridine, in humans

5'-Deoxy-5-fluorouridine (5'-dFUrd) is a new antineoplastic agent which possesses a higher therapeutic index in several experimental tumors compared to other fluoropyrimidines. During a Phase I trial, 5'-dFUrd, 1 to 15 g/sq m/week, was administered to patients as a 25- to 35-min i.v....

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1983-02, Vol.43 (2), p.930
Main Authors: Sommadossi, J P, Aubert, C, Cano, J P, Gouveia, J, Ribaud, P, Mathé, G
Format: Article
Language:English
Subjects:
Colonic Neoplasms - metabolism
Drug Evaluation
Floxuridine - metabolism
Floxuridine - toxicity
Humans
Isomerism
Kinetics
Neoplasm Metastasis
Pancreatic Neoplasms - metabolism
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Summary:5'-Deoxy-5-fluorouridine (5'-dFUrd) is a new antineoplastic agent which possesses a higher therapeutic index in several experimental tumors compared to other fluoropyrimidines. During a Phase I trial, 5'-dFUrd, 1 to 15 g/sq m/week, was administered to patients as a 25- to 35-min i.v. infusion. Plasma kinetics and metabolism of 5'-dFUrd were investigated. The unmetabolized drug was measured by a high-performance liquid chromatography assay. 5-Fluorouracil and 5,6-dihydrofluorouracil, the two detected plasma metabolites, were quantitated by a gas chromatography-mass spectrometry methodology with a detection limit of 0.07 microM for both metabolites. The disposition of 5'-dFUrd in humans at therapeutic doses followed a nonlinear kinetic process. Plasma concentrations of 5-fluorouracil generated in vivo represented approximately 6% of 5'-dFUrd concentrations and the 5-fluorouracil half-life ranged from 8.8 to 27.1 min. High plasma values of 5,6-dihydrofluorouracil (14.5 to 30 microM) were observed in patients, indicating the importance of this pathway in humans.
ISSN:0008-5472