Synergistic antileukemic effect of theophylline and 1,3-bis(2-chloroethyl)-1-nitrosourea

A series of experiments evaluated the antileukemic effect of an agent which elevates cellular cyclic adenosine 3':5'-monophosphate levels by phosphate levels by inhibiting phosphodiesterase. When administered alone, theophylline had only modest antileukemic effects, but it had synergistic...

Full description

Saved in:
Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1980-07, Vol.40 (7), p.2202
Main Authors: DeWys, W D, Bathina, S H
Format: Article
Language:English
Subjects:
Animals
Carmustine - metabolism
Carmustine - therapeutic use
Cell Count
Cell Survival - drug effects
Cyclic AMP - metabolism
Drug Evaluation, Preclinical
Drug Synergism
Drug Therapy, Combination
Leukemia L1210 - drug therapy
Leukemia L1210 - metabolism
Leukocyte Count
Male
Mice
Neoplasm Transplantation
Theophylline - therapeutic use
Time Factors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A series of experiments evaluated the antileukemic effect of an agent which elevates cellular cyclic adenosine 3':5'-monophosphate levels by phosphate levels by inhibiting phosphodiesterase. When administered alone, theophylline had only modest antileukemic effects, but it had synergistic effects when administered with 1,3-bis(2-chloroethyl)-1-nitrosourea. This synergism produced an improved therapeutic index in a dose-response study and in a comparison between antileukemic effects and effects on white blood cell nadirs. Uptake of 1,3-bis(2-chloroethyl)-1-nitrosourea and studies of timing of treatment support the hypothesis that elevation of cyclic adenosine 3':5'-monophosphate levels is the mechanism of the observed synergistic effect.
ISSN:0008-5472