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Na+ channels in pancreatic islet cells

Experiments are reviewed which show that Na+ channels which are pharmacologically identical with those found in spiking neurones are present in the outer membrane of pancreatic beta-cells. In both nerve and beta-cells the neurotoxins veratridine, scorpion toxin, and tetrodotoxin bind to three distin...

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Published in:	Postgraduate medical journal 1981, Vol.57 Suppl 1, p.98
Main Authors:	Richardson, B P, Donatsch, P, Lowe, D A, Taylor, P, Stöcklin, E
Format:	Article
Language:	English
Subjects:	Animals Calcium - metabolism Glucose - pharmacology In Vitro Techniques Insulin - metabolism Insulin Secretion Ion Channels - drug effects Ion Channels - metabolism Islets of Langerhans - drug effects Islets of Langerhans - metabolism Male Rats Scorpions Sodium - metabolism Tetrodotoxin - pharmacology Toxins, Biological - pharmacology Veratridine - pharmacology
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container_title	Postgraduate medical journal
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creator	Richardson, B P Donatsch, P Lowe, D A Taylor, P Stöcklin, E
description	Experiments are reviewed which show that Na+ channels which are pharmacologically identical with those found in spiking neurones are present in the outer membrane of pancreatic beta-cells. In both nerve and beta-cells the neurotoxins veratridine, scorpion toxin, and tetrodotoxin bind to three distinctly separate sites on the sodium channel, the affinity of each of these sites for its respective toxin being similar in the two tissues. The binding sites for veratridine and scorpion toxin exhibit reciprocal, positive, heterotropic cooperativity. The role of these Na+ channels in the physiological regulation of insulin release is discussed.
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In both nerve and beta-cells the neurotoxins veratridine, scorpion toxin, and tetrodotoxin bind to three distinctly separate sites on the sodium channel, the affinity of each of these sites for its respective toxin being similar in the two tissues. The binding sites for veratridine and scorpion toxin exhibit reciprocal, positive, heterotropic cooperativity. 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subjects	Animals Calcium - metabolism Glucose - pharmacology In Vitro Techniques Insulin - metabolism Insulin Secretion Ion Channels - drug effects Ion Channels - metabolism Islets of Langerhans - drug effects Islets of Langerhans - metabolism Male Rats Scorpions Sodium - metabolism Tetrodotoxin - pharmacology Toxins, Biological - pharmacology Veratridine - pharmacology
title	Na+ channels in pancreatic islet cells
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