TOXICOLOGICAL STUDIES ON A NEW MACROLIDE ANTIBIOTIC, MIDECAMYCIN ACETATE (MIOCAMYCIN): PART I-1. ACUTE TOXICITY IN MICE

Miocamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens1, 2). The objective of this study was to determine the acute toxicity of MOM, non-crystalline solid, in male and female mice (Jcl-ICR, SPF, 5-week-old) after single i....

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Bibliographic Details
Published in:Japanese journal of antibiotics 1984/07/25, Vol.37(7), pp.1313-1316
Main Authors: YOKOTA, MASAYUKI, TAKEDA, UETO, ODAKI, MASUZO, SASAKI, HITOSHI, KAWAOTO, HARUO, ITOH, TAKASHI, KOEDA, TAKEMI
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - toxicity
Body Weight - drug effects
Chemical and Drug Induced Liver Injury - pathology
Female
Lethal Dose 50
Leucomycins - toxicity
Liver - pathology
Male
Mice
Mice, Inbred ICR
Miocamycin
Organ Size - drug effects
Rats
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Summary:Miocamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens1, 2). The objective of this study was to determine the acute toxicity of MOM, non-crystalline solid, in male and female mice (Jcl-ICR, SPF, 5-week-old) after single i. p., s. c. and p. o. administration of this material at a dose level of 5,000mg/kg as the maximum physically applicable dose. MOM, non-crystalline solid, exhibited no acute toxicity in the present study. LD0 values were estimated as more than 5,000mg/kg in each route of administration.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.37.1313