TOXICOLOGICAL STUDIES ON A NEW MACROLIDE ANTIBIOTIC, MIDECAMYCIN ACETATE (MIOCAMYCIN): PART III-4. CHRONIC TOXICITY IN BEAGLE DOGS: 26-WEEK-TREATMENT IN MALE DOGS

Miocamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens. The objective of this study was to determine the chronic toxicity of MOM in male Beagle dogs after repeated oral administration of MOM, non-crystalline solid, for 26 w...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1984/07/25, Vol.37(7), pp.1399-1416
Main Authors: YOKOTA, MASAYUKI, TAKEDA, UETO, ODAKI, MASUZO, SASAKI, HITOSHI, NIIZATO, TETSUTARO, KAWAOTO, HARUO, KUMAGAI, KAZUNOBU, SUZUKI, HEIJIRO, SUZUKI, MIDORI, SUGIYAMA, NORIKO, KOEDA, TAKEMI
Format: Article
Language:English
Subjects:
Animals
Dogs
Kidney Tubules - ultrastructure
Leucomycins - toxicity
Male
Miocamycin
Mitochondria, Liver - ultrastructure
Mitochondrial Swelling - drug effects
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Summary:Miocamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens. The objective of this study was to determine the chronic toxicity of MOM in male Beagle dogs after repeated oral administration of MOM, non-crystalline solid, for 26 weeks at b.i.d. dosage of 200, 400, 800 and 1,200mg/kg/day. It is concluded that MOM, non-crystalline solid, did not show any toxic effects in this chronic toxicity study. Therefore, the maximum non-toxic dose is presumed to be 1,200mg/kg/day or more in male Beagle dogs administered orally at b.i.d. for 26 weeks.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.37.1399