TOXICOLOGICAL STUDIES ON A NEW MACROLIDE ANTIBIOTIC, MIDECAMYCIN ACETATE (MIOCAMYCIN): PART IV-4. TOXICITY OF METABOLITES OF MIOCAMYCIN: ACUTE TOXICITY OF Mb2 IN MICE

Miocamycin (MOM) is a derivative of midecamycin1, 2) and is metabolized into 4 main metabolites5). At previous study, LD0 values of Mb1 were estimated more than 5,000 mg/kg in male and female mice7). The object of this study was to evaluate acute toxicity in male and female mice after single oral ad...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1984/08/25, Vol.37(8), pp.1507-1509
Main Authors: YOKOTA, MASAYUKI, TAKEDA, UETO, ODAKI, MASUZO, SASAKI, HITOSHI, KAWAOTO, HARUO, ITOH, TAKASHI, KOEDA, TAKEMI
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - metabolism
Anti-Bacterial Agents - toxicity
Female
Lethal Dose 50
Leucomycins - metabolism
Leucomycins - toxicity
Male
Mice
Miocamycin
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Summary:Miocamycin (MOM) is a derivative of midecamycin1, 2) and is metabolized into 4 main metabolites5). At previous study, LD0 values of Mb1 were estimated more than 5,000 mg/kg in male and female mice7). The object of this study was to evaluate acute toxicity in male and female mice after single oral administration of Mb2, a metabolite of MOM, at a does level of 5,000 mg/kg as the maximum physically applicable dose. It is concluded that LD, values of Mb2 were estimated more than 5,000 mg/kg.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.37.1507